Orringer Lab

Brain tumor research at NYU

We study the origins of glioma and develop cutting-edge tools to improve brain tumor outcomes.

Our research
Left side of a human brain reconstructed from MRI, with the cerebellum visible below the cerebral folds

The origins of glioma

We are interested in elaborating the stochastic processes which underpin glioma formation, a new way at approaching tumor biology.

Heatmap of 20 frontal-enriched genes in microglia, with columns grouped by frontal and non-frontal regions.
Low-grade glioma imaged with stimulated Raman histology
Jiang et al., OpenSRH (2022)

Stimulated Raman histology

Using AI-based field diagnostics, we developed a tool to computationally stain glioma specimens for rapid diagnosis and real-time surgical decision making.

Imaging research

Technologies to improve neurosurgical decision making

Deciding how much tumor to remove while preserving brain function is one of the most complex judgments in neurosurgical oncology. We are developing tools to guide that decision during surgery, including a 15-minute test that measures tumor DNA at the resection margin.

MRI reconstruction of a glioma with four surgical tissue sampling sites marked in yellow.
Murphy et al., Fig. 4D (2024)